Mewtwo Guide (Best Fusions, Stats, How to Catch)

Mewtwo is the strongest Pokémon you can catch in Pokémon Infinite Fusion’s main storyline — a 680-base-stat Psychic juggernaut waiting at the bottom of Cerulean Cave for any trainer strong enough to reach it. In version 6.7.2 it remains the definitive special attacker of the game: 154 Special Attack, 130 Speed, and a coverage movepool that lets it hit virtually everything. If Dragonite is the patient player’s reward, Mewtwo is the endgame’s final exam.

This guide covers everything: Mewtwo’s base stats and abilities, the exact requirements to unlock Cerulean Cave, a step-by-step catching strategy for the level 60 static encounter, the best movesets, whether you can fuse Mewtwo (yes — and the results are absurd), and answers to the most common questions. This is a fan-written guide, not an official resource.

Mewtwo at a Glance

Mewtwo’s stats are in a different league from nearly everything else in the game. Here is the full spread:

• Type: Psychic
• HP: 106
• Attack: 110
• Defense: 90
• Sp. Attack: 154
• Sp. Defense: 90
• Speed: 130
• Total: 680

Mewtwo’s ability is Pressure (opponents use double PP for their moves), with Unnerve as its hidden ability (prevents opponents from eating berries). Pressure is genuinely useful in long legendary battles — it drains the PP of stall tactics — while Unnerve shuts down berry-reliant strategies. Neither defines Mewtwo the way Multiscale defines Dragonite, though; Mewtwo’s stats are the ability.

As a pure Psychic type, Mewtwo is weak to Bug, Ghost, and Dark, resists Fighting and Psychic, and hits Fighting and Poison types super-effectively with STAB. Its real strength is coverage: with moves like Aura Sphere, Ice Beam, Thunderbolt, and Flamethrower available, very few Pokémon can safely switch into it.

How to Unlock Cerulean Cave

Mewtwo is a post-game encounter, and reaching it requires clearing several gates. Here is the full chain:

• Beat the game — become the Kanto Champion first. Cerulean Cave does not open before this.
• Talk to Professor Oak, who will direct you to his colleague, Professor Elm in New Bark Town (Johto).
• Earn at least 2 Johto badges. Professor Elm will then give you HM05 Waterfall.
• Enter Cerulean Cave on Route 4 near Cerulean City. You need Surf, Waterfall, and Flash (or the lantern) to navigate it — surf across the water, climb the waterfall, and light up the dark floors.

The cave itself is a multi-floor dungeon filled with powerful evolved Pokémon in the high 50s, so treat the trip as a gauntlet: bring healing items, Repels, and a balanced team. Mewtwo waits in its chamber at the very end at level 60, as a static encounter — there are no wild Pokémon in its chamber, so once you arrive, it is just you and Mewtwo.

How to Catch Mewtwo

Mewtwo has a very low catch rate and hits extremely hard, so preparation is everything. Save your game in front of it — if the encounter goes wrong, you can reset and try again.

Recommended Team and Items

• A status inducer — something with Sleep (Spore, Hypnosis) or Thunder Wave. Sleep gives the biggest catch-rate boost.
• A False Swipe user to bring Mewtwo to exactly 1 HP without knocking it out. Scyther and Parasect are classic choices.
• A bulky Dark-type (Tyranitar, Umbreon) to safely absorb Mewtwo’s Psychic attacks while you set up — Dark is immune to Psychic.
• 40+ Ultra Balls at minimum; Timer Balls become better than Ultra Balls after 10+ turns, so pack those too.
• Healing items and PP restoration — Mewtwo’s Pressure doubles your PP usage, so long stall attempts drain your moves fast.

The Catching Strategy

Open with your Dark-type to tank Mewtwo’s opening attacks safely. Once it is chipped down, switch to your False Swipe user and cut it to 1 HP — be careful, because at low HP Mewtwo keeps fighting with Recover and strong coverage. Put it to sleep, then start throwing balls. Reapply sleep whenever it wakes up, and switch to Timer Balls once the battle passes turn 10. If Mewtwo uses Safeguard, wait it out or bring your own status through it — do not waste Ultra Balls on a fully awake Mewtwo at high HP.

One more tip: Mewtwo can use Recover, which undoes your False Swipe work. If it keeps healing, consider strategies that block recovery or simply out-damage it — a strong super-effective attacker that can survive one hit is sometimes more reliable than a long stall. Patience wins here; most players catch it within 20–40 balls with the sleep + 1 HP formula.

Mewtwo’s Strengths in Battle

Mewtwo is quite simply the best special sweeper in the game. 154 Special Attack means even resisted hits hurt; 130 Speed means almost nothing outspeeds it without a Choice Scarf or priority; and 106/90/90 bulk means it survives neutral hits that would delete frailer sweepers. It needs no setup to threaten an entire team — it just attacks.

What separates Mewtwo from other strong Psychic-types like Alakazam is the combination of power, speed, and bulk. Alakazam hits hard and fast but folds to any priority move; Mewtwo takes the hit and fires back. That durability also makes it an excellent Calm Mind user — one boost and it becomes functionally unwallable.

Its one real flaw is the shallow defensive typing: pure Psychic gives it three common weaknesses (Bug, Ghost, Dark) and Pursuit-style trapping is a genuine threat. Play Mewtwo as the aggressor — it is at its best forcing switches and punishing them, not sitting on the field taking hits.

Best Moveset for Mewtwo

Calm Mind Sweeper (Standard)

• Calm Mind — boosts Special Attack and Special Defense; one use makes Mewtwo nearly unwallable
• Psychic / Psystrike — primary STAB; Psychic has the Special Defense drop chance, Psystrike hits physically defensive walls on their weaker Defense stat
• Aura Sphere — never misses and destroys Dark and Steel types that resist Psychic
• Ice Beam / Thunderbolt — coverage slot; Ice Beam hits Dragon and Flying types, Thunderbolt hits Water and Flying types

All-Out Attacker

Drop Calm Mind for a fourth coverage move — Flamethrower or Shadow Ball — and give Mewtwo a Life Orb or Choice Specs. This set 2HKOs almost the entire game with correct predictions and needs no setup turn. Shadow Ball deserves special mention: it hits opposing Psychic-types and gives Mewtwo a weapon in mirror matchups.

Bulky Utility

Mewtwo’s 106/90/90 bulk supports a Recover + Calm Mind + two attacks set that outlasts defensive teams. This is the set that breaks stall: Pressure drains the opponent’s PP while Recover and Calm Mind keep Mewtwo healthy and increasingly dangerous. It is slower to get going but almost impossible to stop once set up.

Can You Fuse Mewtwo?

Yes. Despite what some outdated guides claim, the game’s developer has confirmed that the DNA Splicers work on every Pokémon — legendaries included. Mewtwo can be fused with any other Pokémon, and because fused stats are averaged between the parents, Mewtwo’s 680 base stat total supercharges whatever it touches.

That said, think carefully before fusing your only Mewtwo: it is a one-per-save static encounter (outside of special events), so fusing it is permanent for that playthrough unless you have a backup save. Many players keep one “pure” Mewtwo and only fuse in New Game+ style replays or randomized runs.

Mewtwo Fusion Ideas

• Mewtwo + Gengar: the special-attack nightmare — two elite special sweepers combined into one impossibly fast, impossibly strong Ghost/Psychic hybrid.
• Mewtwo + Alakazam: doubles down on Psychic dominance; absurd Special Attack with Speed that outruns nearly everything in the game.
• Mewtwo + Dragonite: physical bulk and Multiscale-style presence meets Mewtwo’s special firepower — a true mixed attacker with 600+ averaged stats on both sides.
• Mewtwo + Tyranitar: Dark typing patches Mewtwo’s Ghost and Dark weaknesses while Sand Stream chips opponents; a bulky offensive hybrid.

Preview any of these in our Pokémon Fusion Tool, verify the stat spreads with the Fusion Calculator, and plan the team around the result with our Team Builder.

Mewtwo vs. Other Legendaries

Where does Mewtwo rank among Infinite Fusion’s 25 legendaries? For raw sweeping power, it is unmatched — nothing else combines 154 Special Attack with 130 Speed. The legendary birds (Articuno, Zapdos, Moltres) are more specialized; the roaming beasts (Raikou, Entei, Suicune) are fast but far weaker offensively; and Lugia and Ho-Oh lean defensive. Mewtwo is the one legendary that fits on literally any team and immediately becomes its best attacker. If you are hunting the rest of them, our Legendary Locations Guide maps every encounter.

Using Mewtwo on Your Team

Mewtwo needs no support to function — it switches in, threatens everything, and forces the opponent to react. The best teammates are ones that remove its checks: a strong Dark-type answer (Fighting coverage of your own, or a Fairy-type), entry hazard support to punish the switches Mewtwo forces, and something that handles faster Choice Scarf revenge killers. Because Mewtwo arrives post-game at level 60, it slots straight into Elite Four rematches, the Battle Factory, and Johto’s toughest fights without any grinding.

For the full Pokédex context on where Mewtwo sits among every catchable Pokémon, browse the Infinite Fusion Dex.

Mewtwo FAQ

Where do you find Mewtwo in Pokémon Infinite Fusion?

Mewtwo is at the end of Cerulean Cave on Route 4 near Cerulean City, at level 60. You need to beat the game, get HM05 Waterfall from Professor Elm in New Bark Town (requires 2 Johto badges), and navigate the cave with Surf, Waterfall, and Flash.

What level is Mewtwo?

The static encounter is level 60. Its chamber has no wild encounters, so you can save directly in front of it and reset if the catch goes wrong.

Can Mewtwo be shiny?

Yes — as a static encounter, Mewtwo can be shiny hunted by saving in front of it and resetting until it shines. See our Shiny Hunting Guide for the full mechanics, odds, and hunting methods.

Can you fuse legendary Pokémon in Infinite Fusion?

Yes. The DNA Splicers work on every Pokémon, including legendaries like Mewtwo. Just remember that Mewtwo is a one-per-save encounter, so fusing it is a permanent decision for that playthrough.

What is Mewtwo weak to?

As a pure Psychic type, Mewtwo is weak to Bug, Ghost, and Dark. Aura Sphere in its own movepool covers Dark and Steel types, which is part of what makes it so hard to wall.

Is Mewtwo better than Mew?

For battling, yes — Mewtwo’s 680 stats and focused offensive profile outclass Mew’s balanced 600 in almost every role. Mew’s advantage is versatility: it can learn every TM. But if you want the strongest Psychic attacker in the game, Mewtwo is the answer.

Conclusion

Mewtwo is the crown jewel of Pokémon Infinite Fusion’s legendary roster — the strongest static encounter in the game, a special sweeper with no real equal, and fusion material that breaks the stat curve. Earning it takes real work: beating Kanto, pushing into Johto, and conquering Cerulean Cave. But the moment that level 60 psychic titan joins your team, the entire post-game bends around it. Make sure you are on the latest version — download Pokémon Infinite Fusion (currently 6.7.2) — then head to Cerulean Cave and claim it.